以下关于POLE和POLD1基因突变说法错误的是()
A.POLE/POLD1突变肿瘤中,74%为MSS或MSI-L
B.在MSS或MSI-L肿瘤中,有POLE/POLD1突变较野生型的OS显著延长
C.在POLE/POLD1突变肿瘤中,MSI-H与MSS/MSI-L患者的OS无统计学差异
D.POLE和POLD1基因突变在所有肿瘤中发生率在5%左右
A.POLE/POLD1突变肿瘤中,74%为MSS或MSI-L
B.在MSS或MSI-L肿瘤中,有POLE/POLD1突变较野生型的OS显著延长
C.在POLE/POLD1突变肿瘤中,MSI-H与MSS/MSI-L患者的OS无统计学差异
D.POLE和POLD1基因突变在所有肿瘤中发生率在5%左右
A.TRH作用缺陷
B.较少家系
C.有典型新生儿甲减表现
D.常有生长缓慢、嗜睡和乏力的表现
E.TRH刺激时,TSH、PRL反应迟钝
The most important preparation for the North Pole exploration is______.
A.a fat layer on your own body
B.a heavy-duty coat
C.the best travel gear
D.dog sledding
From this passage, we know that the magnetic North Pole ______.
A.overlaps exactly on the geographic North Pole
B.is set according to the Earth's magnetic field
C.moves along the Canadian Arctic
D.locates 90 degrees north latitude
Why is Coordinated Universal Time mostly used at the North Pole?
A.Because it is more precise than Green Mean Time.
B.Because it is preferred by astronomers and navigators.
C.Because it is similar to Greenwich Mean Time.
D.Because it is technically based on time zone.
Who was the first undisputed explorer to the North Pole?
A.Frederick Albert Cook.
B.Tom Avery.
C.Santa Claus.
D.Robert Edwin Peary.
What has caused the disputes among countries at the North Pole?
A.The rich natural resources.
B.The unknown frontier.
C.The melting ice.
D.The global warming effect.
North Pole Explorations
If Santa Clans really does reside at the North Pole, he must live a lonely life. The North Pole isn't what most of us would consider a hospitable place as the average winter temperature there is 40 degrees below zero Fahrenheit (华氏温度) (-40 Celsius). And while Santa's reindeer are considered Arctic animals, not much life actually calls the North Pole its permanent home.
For adventurers, the North Pole is comparable to outer space: an unknown frontier that's ripe for exploration--and exploitation. The region doesn't belong to any one country, so there are always disputes about who can lay claim to the untapped natural resources there. And although the prospect of melting ice around. the North Pole isn't pleasant from a global warming standpoint, it could make those resources easier to reach.
North pole location
There are two North Poles. The one most people think of is the geographic North Pole, which is located approximately 450 miles (724 kilometers), north of Greenland, at 90 degrees north latitude. The magnetic North Pole is based on the Earth's magnetic field and is slowly drifting across the Canadian Arctic.
Because all lines of longitude converge (向中聚集) at the North Pole, it's not technically in any time zone (or, it's in every time zone, del)ending on your perspective). As a result, we generally use Coordinated Universal Time (UTC) at the. North Pole. Coordinated Universal Time is used mostly in astronomy and navigation: It's similar to Greenwich Mean Time (the time kept on the Greenwich meridian, longitude zero) but scientifically more precise.
The sun sets at the North Pole in early October. The next sunrise is in early March. In between, there's a continuous twilight as the Earth moves on its axis. As a result of all this, the North Pole is obviously cold. In the winter, when the North Pole is farthest from the sun on the Earth's axis, the average temperature is -40 degrees Fahrenheit (-40 Celsius) during December and January, but can dip into the negative 50s. The seawater beneath the ice of the North Pole is a relatively mild-28 degrees F (-33 C). In the summer, the Pole averages 32 degrees F (0 C). But the North Pole isn't as cold as it used to be.
History of North Pole expeditions
People have always had the desire to explore new plies. Explorers throughout history have been motivated--at least in part--by the promise of fame and fortune, and North Pole exploration is no exception. The first North Pole explorers were in search of the Northwest Passage, a route through the Arctic that would create easier trade--and great wealth--for the country that discovered it. When these explorers came back with tales of diamonds and coal near the Pole, the world started seeing the Arctic as a frozen treasure chest. In fact, a U. S. Geological Survey estimates that nearly 25 percent of the world's undiscovered oil and gas are buried in the Arctic, which is a big reason for the disputes among the countries that are eager to claim the region for themselves.
There were occasional North Pole expeditions in the 18th century (in 1755, the British Parliament offered a reward to the first ship to come within a degree of the Pole), but it wasn't until the early 1900s that things really got going. In 1908, American Frederick Albert Cook was the first person to claim to have reached the North Pole. But his countryman Robert Edwin Peary, with support from Cook's traveling companions, disputed the claim, and Cook was widely discredited.
Peary (with a team of 24 men, 19 sledges and 133 sled dogs) ended up making the first undisputed visit to the North Pole on April 6, 1909. But there's still some controversy attached to the claim, mostly because of Peary's improbable 37-day time frame. Most expeditions of the era took months--at least--to come close to the goal. However, in April 2005, explorer
A.it delivers an undisturbed home for many animals
B.most creatures cannot adapt to its environment
C.only Santa Claus likes living there with his reindeer
D.only a few kinds of creatures can't bear its coldness
A.无症状患者每3-6个月随访一次
B.所有的WM都需要治疗
C.权威治疗指南一致认为,有症状患者应接受治疗
D.WM基因突变量少
E.WM有明确的驱动基因
A.An embryo forms with only ectodermal and endodermal derivatives.
B.Animal cap cells are induced by the vegetal cells to form. meso dermal derivatives.
C.The embryo regulates and forms a normal embryo.
D.Vegetal hemisphere cells are induced by the animal cap cells to form. mesodermal derivatives.
Antarctica differs slightly【C5】______ the Arctic regions. The Arctic is an ocean, covered with【C6】______ packed ice and surrounded by the land masses of Europe, Asia, and North America. The Antarctic is a continent 【C7】______ as large as Europe and Australia 【C8】______ , centered roughly on the South Pole and surrounded by the most【C9】______ water areas of the world—the Atlantic, Pacific and Indian Ocean.
The continental ice pack is more than two【C10】______ high at its center; thus, the air over the Antarctic is far more refrigerated (冰冻的) than it is over the Arctic regions. This cold air falls 【C11】______the land with such force that it 【C12】______ the nearby seas the stormiest in the world and renders【C13】______ those regions whose【C14】______ at the opposite end of the globe are inhabited.【C15】______ , more than a million persons live【C16】______ 2 000 miles of the North Pole in an area that【C17】______ most of Alaska, Siberia, and Scandinavia a【C18】______ rich in forest and mining industries. Except for a handful of【C19】 ______ stations, within the same distance of the South Pole there is not a(an)【C20】______ tree, industry, or settlement.
【C1】
A.extension
B.orbit
C.extent
D.length